Jennifer C. Mandal is a science advisor in the Life Sciences group at Goodwin with a focus on due diligence, freedom to operate analysis, patent drafting, and strategic prosecution of US and foreign patent applications. Dr. Mandal has worked with biotech and life sciences companies on matters in the areas of biology, neuroscience, biosimilars, food science, structural biology, and biophysics.
Dr. Mandal obtained her PhD in Molecular Biophysics and Structural Biology from the University of Pittsburgh in 2018, and held a post-doctoral research fellowship position in Pulmonary, Allergy, and Critical Care Medicine at the University of Pittsburgh from 2019-2022. For her dissertation work, Jennifer primarily utilized multidimensional magic-angle-spinning (MAS) solid state NMR and transmission electron microscopy (TEM) to study aggregation behavior and solid state structures of protein deposits and amyloid fibrils implicated in protein deposition diseases, including cataract and Huntington’s disease. As a post-doctoral fellow, Jennifer used in vitro and murine models to study mitochondrial functioning and the role of the mitochondrial ATP/ADP transporter adenine nucleotide translocase (ANT) in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease. Jennifer has published scientific research manuscripts in several peer-reviewed research journals, including a first-author paper in Nature Communications. She has presented her research at several national and international conferences, including at Biophysical Society.
- Co-Author, “Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils,” J Struct Biol. 6:100077, 2022
- Co-Author, “VEGF receptor promotes hypoxia-induced hematopoietic progenitor proliferation and differentiation,” Front Immunol. 13:882484, 2022
- Co-Author, “NMR identification of a conserved Drp1 cardiolipin-binding motif indispensable for mitochondrial fission," PNAS. 118(29): e2023079118, 2021
- Co-Author, “Protofilament structure and supramolecular polymorphism of aggregated mutant huntingtin exon 1,” J. Mol. Biol., 2020 432(16):4722-4744
- Co-Author, "Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance,” J. Am. Chem. Soc. 140(44):14576–14580, 2018
- Co-Author, “Methionine oxidized Apolipoprotein A-I at the crossroads of HDL biogenesis and amyloid formation,” Fed. Am. Soc. For Exp. Biol. 32(6):2149-2165, 2018
- Co-Author, “Cataract-associated P23T gamma D crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH,” Nature Communications 8:15137, 2017
- Co-Author, "Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core,” Nature Communications 8:15462, 2017
- Co-Author, “On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR,” J. Biomol. NMR 67(3):165-17, 2017
- Co-Author, “Peptide-Directed Assembly of Single-Helical Gold Nanoparticle Superstructures Exhibiting Intense Chiroptical Activity,” JACS 138(41): 13655-13663, 2016
- Co-Author, “Huntingtin exon 1 fibrils feature an interdigitated β-hairpin-based polyglutamine core,” Proc. Nat. Acad. Sci. 113(6):1546-1551, 2016