Advocate for women’s health and wellness. Authoritative expertise in healthcare laws and regulations. Experienced in solutions and structures.

Delphine O’Rourke has tackled some of the most difficult problems in healthcare from the C-suite and board rooms of health companies. She is a partner in the firm’s Life Sciences group and a leader of the Women’s Health and Wellness practice. Ms. O’Rourke is a health law subject matter expert, provides strategic guidance, technical expertise and regulatory counsel to clients.

Ms. O’Rourke develops and executes regulatory solutions on behalf of entrepreneurs, growth companies, healthcare systems, public companies and investors, and works directly with leadership to leverage her clients’ innovative solutions. She focuses her healthcare regulatory practice on compliance with federal laws and regulations governing access, delivery and payment for medical care in the United States including compliance with the Anti-Kickback Statute, Stark Law, OIG civil monetary penalties law, state fraud and abuse provisions, change of ownership, corporate practice of medicine, Medicare and Medicaid reimbursement, laws relating to non-profit health systems. Additionally, Ms. O’Rourke is a fierce advocate for founders in women’s health and partners with them along their journey by providing them with critical strategic and legal advice.

In addition to being a trusted and invaluable advisor for companies transforming the health and wellness industry, Ms. O’Rourke is an experienced health system leader and in-house counsel. Ms. O’Rourke was Associate General Counsel of Ascension, one of the largest healthcare systems in the U.S., and bridges the traditional health system for her clients’ products, services and investments.

Ms. O’Rourke serves on the boards of the Columbia Law School Alumni Association, The Forum of Executive Women, and The Foundation of The Forum of Executive Women. She is Vice-Chair of the Women’s Leadership Council of the American Health Law Association, member of CHIEF (a private network focused on connecting and supporting women leaders), healthcare expert for Endeavor (the world’s leading community of high-impact entrepreneurs) and Fellows Mentor for Summit Impact (a community-powered approach to scaling global impact).





Healthcare Providers

  • Serve as outside healthcare regulatory and contracting counsel for service providers, digital health companies, and supply chain vendors in transactions with health systems, academic medical centers and hospitals
  • Advise women’s health and wellness clients including entrepreneurs, growth and mature clients on critical regulatory issues including, and not limited to, remote provision of healthcare, friendly PC models, prohibition on fee-splitting, changes of ownership, government payor requirements, corporate compliance, patient issues, partnerships and contractual arrangements, value-based contracting, private payor arrangements, licensing, accrediting and enterprise risk management
  • Advise a variety of healthcare providers on compliance with the Anti-Kickback Statute, the Stark Law, OIG civil monetary penalties law, and state fraud and abuse provisions

Private Equity

  • Advised Aldrich Capital Partners in its acquisition of Compliancy Group, a provider of a compliance-tracking solution that primarily tracks HIPAA compliance, serving the small to mid-size healthcare market 
  • Advised Aldrich Capital Partners in its acquisition of Rhythm Management Group Corp., a minority-owned provider of remote monitoring services for cardiac patients
  • Advised Great Hill Partners in its acquisition of a controlling equity stake in Clearwave Parent, Inc. at an enterprise value of $300 million
  • Serve as outside counsel to private equity firms regarding portfolio companies, acquisitions of additional assets, and healthcare regulatory due diligence in connection with transactions
  • Provide corporate and healthcare regulatory counsel to private equity clients in connection with formations and investments in healthcare investment funds
  • Advise private equity companies regarding reimbursement strategies, Medicare and Medicaid requirements, corporate compliance, corporate practice of medicine and “friendly” PC structures
  • Provide healthcare reimbursement advice and counsel to private equity clients investing in healthcare providers, health services and medical devices

Digital Health

  • Advising Cano Health in its of acquisition of Doctor’s Medical Center, a provider of primary care and multi-specialty healthcare services 
  • Advising York Capital Management in its minority investment in Advanced Monitoring Caregiving Inc., a telehealth company that offers remote patient monitoring services 
  • Serve as outside counsel on telemedicine, fraud and abuse and corporate laws to a variety of digital health companies including in the women’s health and wellness industry
  • Develop national growth legal strategies for telemedicine and tele-prescribing companies including counseling on multi-state telemedicine requirements, compliance plans, professional licensing, cross-state medical practice, Medicare and Medicaid reimbursement, physician-patient relationships, tele prescribing frameworks, fraud and abuse, and confidentiality
  • Provide ongoing healthcare regulatory counsel, including fraud and abuse, reimbursement, and privacy, to artificial intelligence and clinical decision platforms in a variety of different sub-industries
  • Advising Cano Health in its of acquisition of University Health Care, Inc., a provider of primary care to communities in South Florida

Healthcare Regulatory for Life Sciences Companies

  • Advised Trillium Therapeutics Inc., an immuno-oncology company developing innovative therapies for the treatment of cancer, in its sale to Pfizer Inc. 

  • Advised Nuvalent, Inc., a preclinical stage biopharmaceutical company focused on creating precisely targeted therapies for patients with cancer, on their $190.6 million initial public offering 
  • Advising Monte Rosa Therapeutics, Inc., a clinical-stage developing a portfolio of novel small molecule precision medicines, on their $222.3 million initial public offering
  • Advising Achilles Therapeutics, a clinical-stage biopharmaceutical company developing precision T cell therapies for the treatment of cancer, on its $175.5 million initial public offering
  • Advising Autolus Therapeutics plc, a clinical-stage biopharmaceutical company developing next-generation, programmed T cell therapies for the treatment of cancer, on its $115 million follow-on offering
  • Advising the underwriters in Sensei Biotherapeutics, a clinical-stage biopharmaceutical company focused on the discovery, development and delivery of the next generation of immunotherapies for the treatment of cancer and infectious diseases, on its $133 million initial public offering
  • Advising Kingswood Capital Management, LP, a private investment firm primarily focused on investing in businesses in transition, in connection with its acquisition of Cost Plus World Market from Bed Bath and Beyond Inc.
  • Advising Collective Medical Technologies, a real-time care collaboration network used by payors and healthcare organizations to improve patient outcomes, in connection with its sale to PointClickCare Corp. for approximately $600 million
  • Advising the Special Committee of the Board of Directors of NantKwest in connection with the company’s agreement to merge with ImmunityBio in a stock-for-stock transaction
  • Advising Achilles Therapeutics, a biopharmaceutical company developing personalized cancer immunotherapies, on the completion of its £52.7 million Series C
  • Advising a clinical-stage biotechnology company advancing new immunometabolic therapies for cancer in a Series B Preferred Stock financingAdvising a growth equity investment group in connection with the purchase of Series B Preferred Stock of a pre-clinical life sciences company studying the proteins that drive cancer and other diseases
Professional Activities

Ms. O’Rourke is a thought leader, global speaker and lectures at Columbia Law School on the business of health and the law. She was recognized by The Best Lawyers in America for her work in health care law for 2022.

Ms. O’Rourke is a member of the American Bar Association, American Health Lawyers Association, where she serves as Vice Chair of the Women’s Leadership Committee, as well as the New York and Pennsylvania State Bar Associations.

Ms. O’Rourke is also serving as Legal Expert in Residence for Women of Wearables, Advisory Board Member for MDisrupt and The Invisible Girl Project, Board Member for the Columbia Law School Alumni Association and The Forum of Executive Women, and member of CHIEF.

Professional Experience

Ms. O’Rourke spent over a decade of dedication in legal and executive roles with Ascension, the second largest healthcare system and largest nonprofit health system in the U.S. and the largest Catholic health system in the world.


Ms. O'Rourke has been recognized by The Best Lawyers in America Best Lawyers for her work in Health Care Law 2022.

Ms. O'Rourke was a recommended lawyer for Healthcare and Education by The Legal 500 in 2021 and 2022, respectively.

In The News









J.D., 2001
Columbia University
(Harlan Fiske Stone Scholar)
B.S., 1996
Georgetown University
(cum laude)


2002 U.S. District Court for the Eastern District of Pennsylvania, Honorable Legrome D. Davis



New York
New Jersey


U.S. Supreme Court
U.S. District Court for the Southern District of New York
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