Victoria R. Tenge

Victoria Tenge is a Science Advisor in Goodwin’s Life Sciences practice group. She assists clients with patent preparation, patent prosecution, freedom to operate and patentability analyses, and IP diligence. Dr. Tenge works with clients spanning several life sciences branches including focuses on antibody therapies, genetic engineering, gene therapies, and cell therapies. 

Dr. Tenge has over a decade of research experience in the life sciences. Her technical expertise includes molecular virology, microbiology, biochemistry, intestinal biology, and use of 3D and 2D stem cell organoid technologies, and translational research. Dr. Tenge’s technical experience also includes use of genetic and biochemical techniques including CRISPR/Cas9- and transposon-based genetic manipulation of organoids and the use of yeast-based systems for the study of protein-protein interactions. 

Dr. Victoria Tenge’s technical expertise includes molecular virology, microbiology, biochemistry, and intestinal biology. Prior to joining Goodwin, Dr. Tenge was a Postdoctoral Fellow at Baylor College of Medicine under the guidance of Dr. Mary Estes where her research focused on the role of bile acids in human norovirus replication in the small intestine. Dr. Tenge received her PhD under the guidance of Dr. Estes and Dr. Robert Atmar during which she contributed to the development of a novel laboratory replication system for previously uncultivatable human noroviruses.

Selected publications:

• Tenge VR, Murakami K, Salmen W, Lin SC, Crawford SE, Neill FH, Prasad BVV, Atmar RL, Estes MK. Bile Goes Viral. Viruses. 2021 May 27;13(6):998. doi: 10.3390/v13060998
• Tenge VR, Hu L, Prasad BVV, Larson G, Atmar RL, Estes MK, Ramani S. Glycan Recognition in Human Norovirus Infections. Viruses. 2021 Oct 14;13(10):2066. doi: 10.3390/v13102066
• Murakami K*, Tenge VR*, Karandikar UC*, Lin SC, Ramani S, Ettayebi K, Crawford SE, Zeng XL, Neill FH, Ayyar BV, Katayama K, Graham DY, Bieberich E, Atmar RL, Estes MK. Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1700-1710. doi: 10.1073/pnas.1910138117
• Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 Sep 23;353(6306):1387-1393. doi: 10.1126/science.aaf5211
• Additional publications can be found at: https://pubmed.ncbi.nlm.nih.gov/?term=victoria%20tenge&sort=pubdate

*Authors contributed equally