Michael Harden

Michael Harden is a science advisor in Goodwin’s Business Law department and a member of its Intellectual Property practice. He uses his expertise in the life sciences to assist clients with patent drafting, patent prosecution, IP diligence, and freedom to operate analyses. He joined Goodwin in 2021.

Prior to joining Goodwin, Dr. Harden earned his PhD from the Massachusetts Institute of Technology, where he carried out his doctoral research in the laboratory of Alan Grossman. For his dissertation work, he used a variety of molecular biology, genetic, and microscopy techniques to investigate the molecular mechanisms underlying how mobile genetic elements interact with their host cells.

• Harden MM, Anderson ME, Grossman AD. 2022. A CRISPR interference screen reveals a role for cell wall teichoic acids in conjugation in Bacillus subtilis. Mol. Microbiol. 117(6):1366-83
• Johnson CM, Harden MM, Grossman AD. 2022. Interactions between mobile genetic elements: An anti-phage gene in an integrative and conjugative element protects host cells from predation by a temperate bacteriophage. PLoS Genet 18(2):e1010065
• Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. 2019. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol 4(2):244-50
• Patterson HC, Gerbeth C, Thiru P, Vogtle NF, Knoll M, Shahsafaei A, Samocha KE, Huang CX, Harden MM, Song R, Chen C, Kao J, Shi J, Salmon W, Shaul YD, Stokes MP, Silva JC, Bell GW, MacArthur DG, Ruland J, Meisinger C, Lodish HF. 2015. A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. PNAS 112(42):E5679-88
• Harden MM, He A, Creamer K, Clark MW, Hamdallah I, Martinez KA, Kresslein RL, Bush SP, Slonczewski JL. 2015. Acid-adapted strains of Escherichia coli K-12 obtained by experimental evolution. Appl Environ Microbiol 81(6):1932-41
• Riggins DP, Narvaez MJ, Martinez KA, Harden MM, Slonczewski JL. 2013. Escherichia coli K-12 survives anaerobic exposure at pH 2 without RpoS, Gad, or hydrogenases, but shows sensitivity to autoclaved broth products. PLoS One 8(3):e56796