Matt Wheeler

A partner in Goodwin’s Life Sciences group and Patent Prosecution practice, Dr. Matt Wheeler provides strategic patent counseling to clients on a wide variety of technologies. Matt’s scientific expertise includes antibodies, biologics, diagnostics, and medical devices.

Matt works with clients at all stages, from start-ups to public companies, to develop and implement global patent strategies. His counseling experience includes freedom to operate analysis; due diligence for mergers and acquisitions, private financings, and public markets; and all stages of preparation and prosecution of patent filings in the US and around the world, including post-grant procedures.

• Co-author with J. Pitman, D. Lloyd, R. Glynne, J. Walker, and N. Gekakis, “Jack Lalanne, a gain-of-function mutation in mouse adenylate cyclase 3 that protects against diet-induced obesity,” 9(10) PLoS ONE e110226, October 2014
• Co-author with N. Gekakis, “Hsp90 modifies Ppar? activity in a mouse model of non-alcoholic fatty liver disease,” 55(8) Journal of Lipid Research 1702-1710, June 2014
• Co-author with Y. Prabhu, E.H. Blanco, M. Liiu, JR. Peinado, N. Gekakis, P. Arvan, and I. Lidberg, “Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function,” 155(7) Endocrinology 2391-2401, May 2014
• Co-author with N. Gekakis, “Defective ER Associated Degradation of a Model Luminal Substrate in Yeast Carrying a Mutation in the 4th ER Luminal Loop of Sec61p.”,” 427(4) Biochemical and Biophysical Research Communications 768-73, November 2012
• Co-author with D. Lloyd and N. Gekakis, “A Point Mutation in Sec61a1 Leads to Diabetes and Hepatosteatosis in Mice,” 59(2) Diabetes 460-70, February 2012
• Co-author with N. Mahadevan, J. Rodvold, G. Almanza, A. Fernandez, and M. Zanetti, “ER stress drives Lipocalin 2 transcription in prostate cancer cells in an NF-kB-dependent manner,” 11(1) BMC Cancer 229, June 2011
• Co-author with A. Franco, G. Almanza, J.C. Burns, and M. Zanetti, “Endoplasmic reticulum Stress Drives a Regulatory Phenotype in Human T-Cell Clones,” 266(1) Cell Immunology 1-6, September 2010
• Co-author with M. Rizzi, R. Sasik, G. Almanza, G. Hardiman, and M. Zanetti, “KDEL retained Antigen in B Lymphocytes Induces a Pro-inflammatory Response: A Possible Role for ER Stress in Adaptive T cell Immunity,” 181(1) Journal of Immunology 256-64, July 2008
• Co-author with X. Cortez-Gonzalez, R. Frazzi, and M. Zanetti, “Mechanisms of Internalization and Activation by Plasmid DNA in B lymphocytes,” 25(3-4) International Reviews of Immunology, May-August 2006
• Co-author with X. Cortez-Gonzalez, I. Pellicciotta, M. Gerloni, P. Castiglioni, P. Lenert, and M. Zanetti, “TLR9 Independent Activation of B Lymphocytes by Bacterial DNA,” 25(5) DNA Cell Biology 253-61, May 2006
• Co-author with M. Rizzi, M. Gerloni, A.S. Sirvastava, K. Schuler, E. Carrier, and M. Zanetti, “In utero DNA immunisation. Immunity over tolerance in fetal life,” 23(33) Vaccine 4273-82. July 2005
• Co-author with M. Zanetti, P. Castiglioni, and M. Rizzi, “B lymphocytes as antigen-presenting cellbased genetic vaccines,” 199 Immunology Reviews 264-78, June 2004
• Co-author with G. Filcai, M. Gerloni, M. Rizzi, M. Castiglioni, H.D. Ghang, R. Fiocca, and M. Zanetti, “Spontaneous transgenesis of human B lymphocytes,” 11(1) Gene Therapy 42-51, January 2004